Reprospher 100 C18-NE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with octadecyl ligands. The phase is non-endcapped (NE), meaning residual silanol groups on the silica surface remain active. This enhances polar selectivity and allows additional ion-exchange interactions — particularly beneficial for separating basic, polar, or structurally related compounds. This non-endcapped phase provides an orthogonal retention mechanism compared to fully endcapped C18 materials, making it ideal for method development, selectivity screening, and the separation of challenging analytes.
Reprospher 100 C18-NE from Dr. Maisch HPLC GmbH delivers unique reversed-phase selectivity – ideal for challenging analytes that require combined hydrophobic and polar interaction in HPLC.
Non-endcapped C18 phase – USP L1 classification
Fully porous, high-purity silica with 100 Å pore size
Enhanced polar interaction and secondary retention effects
Strong hydrophobic retention with ion-exchange contribution
Available in 1.7 µm, 1.8 µm, 3 µm, and 5 µm particle sizes
Basic compounds and polar drug substances
Retention tuning of ionizable analytes
Method development with orthogonal selectivity
Resolution of structurally related or tailing-prone compounds
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 15 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C18-NE, 1.7 µm | rs117.90. |
| Reprospher 100 C18-NE, 1.8 µm | rs118.90. |
| Reprospher 100 C18-NE, 3 µm | rs13.90. |
| Reprospher 100 C18-NE, 5 µm | rs15.90. |