Reprospher 100 C4-Aqua is a specially modified reversed-phase HPLC column from Dr. Maisch HPLC GmbH, designed for robust operation under 100% aqueous conditions. Based on high-purity, fully porous silica with a 100 Å pore size, this column is bonded with short-chain butyl ligands and an embedded polar functionality that enhances wetting and retention of polar compounds. Thanks to its unique Aqua-compatible surface chemistry, the column maintains stable retention and excellent peak shape for polar and moderately hydrophobic analytes, even in highly aqueous mobile phases — ideal for LC-MS, bioanalytical, and pharmaceutical applications.
Reprospher 100 C4-Aqua from Dr. Maisch HPLC GmbH combines aqueous compatibility with short-chain reversed-phase selectivity – a smart solution for polar analytes and water-rich HPLC separations.
Butyl C4 phase with embedded polar functionality – suitable for 100% aqueous eluents
Fully porous silica with 100 Å pore size
Enhanced retention of polar analytes in water-rich mobile phases
Suppressed silanol interactions and excellent peak symmetry
Available in 5 µm, 10 µm and 30 µm particle sizes
Reversed-phase separations under highly aqueous conditions
Polar drugs, peptides, and hydrophilic metabolites
LC-MS compatible methods without ion-pairing reagents
Bioanalytical and pharmaceutical method development
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C4 |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| Endcapping | Yes |
| Carbonload | 6 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C4-Aqua, 5 µm | rs15.4aq. |
| Reprospher 100 C4-Aqua, 10 µm | rs10.4aq. |
| Reprospher 100 C4-Aqua, 30 µm | rs130.4aq. |