Reprospher 100 C4-DE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with butyl ligands. The “DE” (double endcapped) modification refers to a specially optimized endcapping process that significantly reduces residual silanol activity. This improves peak shape and reproducibility for basic or ionizable compounds, especially under low-pH mobile phase conditions. With its lower hydrophobicity compared to C18 or C8, Reprospher 100 C4-DE allows faster elution of strongly retained compounds and offers complementary selectivity for method development and stability-indicating assays.
Reprospher 100 C4-DE from Dr. Maisch HPLC GmbH delivers reliable reversed-phase performance with enhanced deactivation – ideal for basic analytes and robust HPLC method development.
Butyl (C4) bonded reversed-phase phase with advanced deactivation
Fully porous silica with 100 Å pore size
Improved peak shape for basic and ionizable analytes
Reduced silanol activity and enhanced reproducibility
Basic drug substances and ionizable small molecules
Stability-indicating methods with tailing-prone compounds
Reversed-phase separations under acidic pH conditions
Orthogonal method development in pharmaceutical and chemical QC
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C4 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 7 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C4-DE, 5 µm | rs15.4de. |