Reprospher 100 C8-DE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, designed for reliable separations of basic and ionizable analytes. It is based on high-purity, fully porous silica with a 100 Å pore size and bonded with octyl ligands. The DE (double endcapping) modification significantly reduces residual silanol activity, minimizing peak tailing and enhancing retention stability — especially for basic and polar compounds. With moderate hydrophobicity and improved surface deactivation, Reprospher 100 C8-DE is an excellent choice for pharmaceutical and chemical analysis requiring precise and reproducible reversed-phase separations.
Reprospher 100 C8-DE from Dr. Maisch HPLC GmbH combines moderate reversed-phase retention with advanced surface deactivation – ideal for demanding separations of ionizable and tailing-prone analytes.
Octyl (C8) bonded reversed-phase phase with advanced deactivation
Fully porous silica with 100 Å pore size
Reduced silanol activity for improved peak shape of basic analytes
Balanced retention for moderately hydrophobic compounds
Available from 1.7 µm to 10 µm particle sizes
Separation of basic drug substances and excipients
Stability-indicating reversed-phase methods
Method development with improved peak symmetry
Routine pharmaceutical QC and impurity profiling
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 10 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C8-DE, 1.7 µm | rs117.8de. |
| Reprospher 100 C8-DE, 1.8 µm | rs118.8de. |
| Reprospher 100 C8-DE, 2 µm | rs12.8de. |
| Reprospher 100 C8-DE, 2.5 µm | rs125.8de. |
| Reprospher 100 C8-DE, 3 µm | rs13.8de. |
| Reprospher 100 C8-DE, 3.5 µm | rs135.8de. |
| Reprospher 100 C8-DE, 5 µm | rs15.8de. |
| Reprospher 100 C8-DE, 10 µm | rs10.8de. |