Reprospher 100 C8-NE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, featuring a non-endcapped octyl (C8) bonded phase on high-purity, fully porous silica with a 100 Å pore size. The absence of endcapping leaves residual silanol groups accessible, allowing enhanced polar interactions and ion-exchange effects. This makes Reprospher 100 C8-NE particularly valuable for method development and the separation of ionizable, basic, or highly polar analytes. Its unique selectivity profile provides an orthogonal alternative to standard endcapped reversed-phase columns, aiding in the resolution of closely related compounds and offering sharper insights during robustness studies.
Reprospher 100 C8-NE from Dr. Maisch HPLC GmbH offers distinct selectivity and enhanced polar interaction – ideal for advanced reversed-phase separations requiring fine-tuned control of silanol-mediated retention.
Octyl (C8) bonded reversed-phase phase without endcapping (NE)
Fully porous silica with 100 Å pore size
Increased silanol activity for polar interaction and alternative selectivity
Suitable for method development and retention tuning
Available in 5 µm
Separation of basic and ionizable analytes with enhanced silanol interaction
Resolution of isomeric or structurally similar compounds
Method scouting with orthogonal selectivity to endcapped C8/C18 columns
Retention tuning of polar compounds in reversed-phase HPLC
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 9 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C8-NE, 5 µm | rs15.80. |