Reprospher 100 Diol-DE is a polar HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 100 Å pore size and functionalized with diol groups. The additional endcapping surface modification minimizes residual silanol activity, resulting in better peak shape, improved reproducibility, and reduced tailing — especially for polar and ionizable compounds.
This neutral, hydrophilic phase supports both normal-phase and HILIC retention mechanisms, making it particularly suitable for the analysis of carbohydrates, polyols, and polar drugs in aqueous or organic-rich mobile phases.
Reprospher 100 Diol-DE from Dr. Maisch HPLC GmbH provides improved polar selectivity and peak shape – an ideal column for demanding HILIC and normal-phase separations of highly polar compounds.
Diol-bonded phase with deactivated silanol surface – USP L20 equivalent
Suitable for HILIC and normal-phase separations
Fully porous silica with 100 Å pore size
Enhanced peak symmetry and reduced secondary interactions
Available in 5 µm
Carbohydrates, polyols, and sugar alcohols
Polar drug substances and excipients
HILIC separations in LC-MS workflows
Normal-phase chromatography of hydrophilic analytes
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | Diol |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 7 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 Diol-DE, 5 µm | rs15.dde. |