Reprospher Acidosil-C is an HPLC column from Dr. Maisch HPLC GmbH, based on ultra-pure, fully porous spherical silica functionalized with carboxyl groups. This modification provides weak cation exchange (WCX) properties, enabling selective retention of positively charged and basic analytes through ionic interactions. The carboxylic functionality offers pH-dependent ion-exchange capacity, making the column especially useful for the separation of amines, alkaloids, peptides, and other basic compounds, while maintaining robust mechanical and chemical stability for reproducible performance.
Reprospher Acidosil-C from Dr. Maisch HPLC GmbH delivers reliable WCX performance with COOH-functional selectivity – ideal for laboratories requiring cation-exchange separations of basic compounds in complex matrices.
Weak cation exchange phase with carboxyl (–COOH) groups
Selective retention of basic and positively charged analytes
Fully porous, high-purity spherical silica for consistent separations
Suitable for aqueous buffers and pH-controlled chromatography
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 5 µm and 10 µm particle sizes
Ion-exchange chromatography of amines, alkaloids, and metabolites
Separation of peptides and small biomolecules with positive charge
Method development for pH-dependent ionic interactions
Pharmaceutical and bioanalytical workflows involving basic analytes
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | COOH |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| Carbonload | 7 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher Acidosil-C, 5 µm | rs15.ch. |
| Reprospher Acidosil-C, 10 µm | rs10.ch. |