Ultrasep ES Amid RP18AE

Endcapped Polar-Embedded C18 Column for Robust and Selective HPLC

Ultrasep ES Amid RP18AE is a silica-based HPLC column with a polar-embedded amidic C18 bonded phase and endcapping. The embedded amide group provides enhanced polar selectivity and improves peak symmetry for basic analytes, while the endcapping reduces residual silanol activity, ensuring high reproducibility and sharp peaks.

This combination of polar and hydrophobic retention makes the column ideal for complex mixtures, stability-indicating assays, and pharmaceutical analysis, where robust performance under harsh pH and temperature conditions is required.

Ultrasep ES Amid RP18AE delivers enhanced polar selectivity, minimized silanol interactions, and robust performance – the reliable choice for challenging reversed-phase HPLC separations.

Key Features:

  • Silica-based stationary phase with polar-embedded amidic C18 bonded phase

  • Endcapped for minimized silanol activity and sharper peaks

  • Strong hydrophobic retention combined with polar selectivity

  • Excellent robustness under wide pH and temperature ranges

  • Available particle size: 5 µm

Typical Applications:

  • Pharmaceutical impurity profiling and drug substance analysis

  • Separation of polar and basic compounds with improved peak shapes

  • Stability-indicating assays under demanding mobile phase conditions

  • Complex mixture analysis in environmental, food, and chemical testing

Specifications

Request Product
Particle Size
  • 5 µm
Pore Size 100 Å
Particle Type
USP Code
Endcapping Yes
pH Range 2 - 8

Material Number

Phase Material Number
Ultrasep ES Amid RP18AE, 5 µm u15.a9ae.
Ultrasep ES Amid RP18A Ultrasep ES Amid RP18AM

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